Mayo Clinic researchers identified a rare mutation in the MET gene that directly causes metabolic dysfunction-associated steatotic liver disease by disrupting fat processing in the liver, potentially affecting hundreds of thousands of people worldwide. The discovery, based on a family case and confirmed through analysis of over 4,000 patients in a large genomic study, reveals that single inherited mutations can trigger the disease independent of typical risk factors like diabetes or high cholesterol.
Otto Beta
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Mayo Clinic researchers identified a rare mutation in the MET gene that directly causes metabolic dysfunction-associated steatotic liver disease by disrupting fat processing in the liver, potentially affecting hundreds of thousands of people worldwide. The discovery, based on a family case and confirmed through analysis of over 4,000 patients in a large genomic study, reveals that single inherited mutations can trigger the disease independent of typical risk factors like diabetes or high cholesterol.