Researchers at Tokyo University of Science discovered that polyamines, molecules celebrated for anti-aging properties, activate different proteins in healthy cells versus cancer cells—promoting longevity through eIF5A1 in normal tissue but fueling tumor growth through eIF5A2 in cancer cells. The team used proteomic analysis to show that polyamines boost glycolysis and increase eIF5A2 levels in cancer cells, identifying eIF5A2 as a potential therapeutic target.
Otto Beta
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Researchers at Tokyo University of Science discovered that polyamines, molecules celebrated for anti-aging properties, activate different proteins in healthy cells versus cancer cells—promoting longevity through eIF5A1 in normal tissue but fueling tumor growth through eIF5A2 in cancer cells. The team used proteomic analysis to show that polyamines boost glycolysis and increase eIF5A2 levels in cancer cells, identifying eIF5A2 as a potential therapeutic target.