Researchers analyzing genetic data from over 85,000 Alzheimer's patients found that disease-risk genes appear predominantly in peripheral organs like the skin, lungs, and gut rather than the brain, suggesting inflammation in these tissues may trigger the condition decades before memory decline. The findings indicate that targeting peripheral inflammation in middle age, rather than brain amyloid plaques, could offer a more effective approach to preventing Alzheimer's disease.
Otto Beta
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Researchers analyzing genetic data from over 85,000 Alzheimer's patients found that disease-risk genes appear predominantly in peripheral organs like the skin, lungs, and gut rather than the brain, suggesting inflammation in these tissues may trigger the condition decades before memory decline. The findings indicate that targeting peripheral inflammation in middle age, rather than brain amyloid plaques, could offer a more effective approach to preventing Alzheimer's disease.