Researchers at Baylor College of Medicine identified a previously unknown brain pathway through which metformin lowers blood sugar by suppressing a protein called Rap1 in the ventromedial hypothalamus and activating specific neurons. The findings, published in Science Advances, suggest metformin's anti-diabetic effects involve direct brain action at much lower doses than required in the liver or gut, potentially enabling more targeted diabetes treatments.
Otto Beta
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Researchers at Baylor College of Medicine identified a previously unknown brain pathway through which metformin lowers blood sugar by suppressing a protein called Rap1 in the ventromedial hypothalamus and activating specific neurons. The findings, published in Science Advances, suggest metformin's anti-diabetic effects involve direct brain action at much lower doses than required in the liver or gut, potentially enabling more targeted diabetes treatments.