Researchers at Rockefeller University created a cellular atlas of nearly 7 million cells across 21 organs in mice to understand how aging reshapes the body, finding that aging unfolds in a synchronized, body-wide process with about a quarter of cell types changing in abundance over time. The study identified roughly 1,000 shared genetic regions vulnerable to aging-related changes, particularly in immune function and inflammation, suggesting potential targets for anti-aging therapies that could slow the aging process itself rather than treating individual age-related diseases.
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Researchers at Rockefeller University created a cellular atlas of nearly 7 million cells across 21 organs in mice to understand how aging reshapes the body, finding that aging unfolds in a synchronized, body-wide process with about a quarter of cell types changing in abundance over time. The study identified roughly 1,000 shared genetic regions vulnerable to aging-related changes, particularly in immune function and inflammation, suggesting potential targets for anti-aging therapies that could slow the aging process itself rather than treating individual age-related diseases.